The cytoplasm gets some new threads

Heart Repair Gets New Muscle

Average earth temperatures rose 0.6 oC over the last century, according to the latest Intergovernmental Panel on Climate Change. But that increase pales in comparison to the 1.4–5.8 oC expected increase over this century. As temperatures climb, climate models predict that high-latitude, high-altitude regions like Yellowstone National Park will experience shorter winters and earlier snow melts. ...

FoxP3 gets a new gig

On page 1141, the one-trick transcription factor FoxP3 reveals a new function. According to Chang and colleagues, FoxP3 does more than just drive regulatory T (T reg) cell development; it also promotes the proliferation of developing thymocytes. FoxP3 is required for the development of CD4 CD25 T reg cells, which subdue the activation of conventional T cells and thus protect against chronic inf...

Utrophin gets a new look

In This Issue In This Issue trophin, a member of the spectrin superfamily of actin-binding proteins ubiquitously expressed in human cells, helps link the actin cytoskeleton to the extracellular matrix. Galkin et al. report on page 231 that a newly developed image analysis method identifies two different modes of utrophin binding to F-actin. The findings contradict earlier studies on utrophin–ac...

Some threads in the development of early operating systems

This paper discusses many of the important themes in design of the early operating systems and their libraries. Historically, the library preceded the development of the early batch system but many of its utility functions gradually migrated to the system proper. Important ideas concerning system structure which were further elaborated in the sixties are briefly discussed.

New Faculty Orientation Gets a Facelift